PLATELETS AND THROMBOPOIESIS Cysteinyl leukotriene overproduction in aspirin-exacerbated respiratory disease is driven by platelet-adherent leukocytes
نویسندگان
چکیده
1Department of Medicine, Harvard Medical School, Boston, MA; 2Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Boston, MA; 3Jeff and Penny Vinik Center for Allergic Disease Research, Boston, MA; 4Department of Surgery, Harvard Medical School, Boston, MA; 5Division of Otolaryngology, Brigham and Women’s Hospital, Boston, MA; 6Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University, Nashville, TN; and 7Department of Pediatrics, Harvard Medical School, Boston, MA
منابع مشابه
Newly Formed Reticulated Platelets Undermine Pharmacokinetically Short-Lived Antiplatelet Therapies
OBJECTIVE Aspirin together with thienopyridine P2Y12 inhibitors, commonly clopidogrel, is a cornerstone of antiplatelet therapy. However, many patients receiving this therapy display high on-treatment platelet reactivity, which is a major therapeutic hurdle to the prevention of recurrent thrombotic events. The emergence of uninhibited platelets after thrombopoiesis has been proposed as a contri...
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Essential thrombocythemia (ET) is characterized by enhanced platelet generation and thrombotic complications. Oncedaily low-dose aspirin incompletely inhibits platelet thromboxane A2 (TXA2) in the majority of ET patients. In the present study, we investigated the determinants of aspirin-insensitive platelet TXA2 biosynthesis and whether it could be further suppressed by changing the aspirin dos...
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The overall picture of platelet abnormalities in diabetes mellitus (DM), including altered adhesion and aggregation, is hypersensitivity of diabetic platelets to agonists. "Primed" diabetic platelets respond more frequently even to subthreshold stimuli, sooner become exhausted, consumed and finally hyposensitive, thus contributing to accelerated thrombopoiesis and release of 'fresh' hyperreacti...
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An association between platelets, angiogenesis, and cancer has long been recognized, but the mechanisms linking them remains unclear. Platelets regulate new blood vessel growth through numerous stimulators and inhibitors of angiogenesis by several pathways, including differential exocytosis of angiogenesis regulators. Herein, we investigated the differential release of angiogenesis stimulators ...
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ticulated platelets in ET draws attention to another major mechanism—namely, COX-1 activity in newly released platelets not inhibited by the once-daily low-dose aspirin. This is because of the relatively short half-life of aspirin in plasma. In states with rapid platelet generation, one daily dose of low-dose aspirin may be insufficient because of the immense capacity of bone marrow to accelera...
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